Watch a brief video on how to properly apply REGRANEX Gel

Decide if you or your home caregiver will be the one applying REGRANEX Gel to your sore each day. Apply REGRANEX Gel at the same time each day — your application schedule can work around daily foot checks:

  • Apply in the am, change dressing in the pm
  • Apply in the pm, change dressing in the am

1. Prepare

  • Wash hands well
  • Carefully measure the amount of REGRANEX Gel that your healthcare provider tells you to use
    — Your healthcare provider may change the amount needed as the sore heals and becomes smaller
  • Squeeze the amount of REGRANEX Gel needed on a clean, firm, non-absorbable surface such as wax paper

TIP: Do not let tip of REGRANEX Gel tube touch ulcer or any other surface.

2. Apply

  • Use application aid to spread REGRANEX Gel in thin, even layer (about 1/16 inch) over the entire area of the sore

TIP: Thickness of gel to be applied should be about the same thickness as a penny.

3. Cover

  • Cover area with a saline moistened gauze dressing

After about 12 hours, gently remove the dressing and rinse sore with saline or water to remove rest of REGRANEX Gel. Cover sore with new saline moistened gauze dressing (without REGRANEX Gel) until your next application.

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Good wound care alone may not be enough to heal a diabetic foot sore. REGRANEX Gel can help.

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Important Safety Information

People who use 3 or more tubes of REGRANEX (becaplermin) Gel may have an increased risk of death from cancer.

REGRANEX Gel is a man-made protein medicine that is used with other ulcer care practices (such as good wound care) to treat diabetic sores (ulcers) of your legs or feet that are deeper than just your skin, in people who have good blood supply to the legs.

Do not use REGRANEX Gel if you have a skin tumor at the area where you apply the product.

Before you use REGRANEX Gel, tell your healthcare provider if you:

If you decide to use REGRANEX Gel, use the product exactly as your healthcare provider tells you to use it. This includes following your healthcare provider's instructions about not putting weight on the affected leg and foot (non-weight bearing).

Keep REGRANEX Gel and all medicines out of the reach of children. Do not use REGRANEX Gel for a condition for which it was not prescribed. Do not give REGRANEX Gel to other people, even if they have the same symptoms that you have. It may harm them.

Read the Medication Guide before you start using REGRANEX Gel and each time you get a refill. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.

Important Safety Information


An increased rate of mortality secondary to malignancy was observed in patients treated with 3 or more tubes of REGRANEX (becaplermin) Gel, 0.01% in a postmarketing retrospective cohort study. REGRANEX Gel should only be used when the benefits can be expected to outweigh the risks. REGRANEX Gel should be used with caution in patients with known malignancy.

Important Safety Information

People who use 3 or more tubes of REGRANEX (becaplermin) Gel may have an increased risk of death from cancer.

You should talk with your healthcare provider about the possible benefits and risks to you if you use more than 3 tubes of REGRANEX Gel. If you already have cancer, you and your healthcare provider should carefully consider whether you will use REGRANEX Gel.