REGRANEX gel is the first and only FDA-approved recombinant platelet-derived growth factor (PDGF) therapy for diabetic neuropathic ulcers
Endogenous PDGF is the trigger that initiates healing by attracting repair cells to wounds7
Platelet-derived growth factor (PDGF) works to
- Stimulate fibroblast proliferation to increase growth of granulation tissue6
- Increase the rate of re-epithelialization and revascularization6
- Promote collagen production6
Find out more about the four stages of healing.
Platelets release PDGF to initiate the chemotaxis of neutrophils, macrophages, smooth muscle cells, and fibroblasts.7
Neutrophils remove foreign material, bacteria and nonfunctional host cells, and damaged matrix components from the wound site.7
Fixed tissue monocytes are activated to become wound macrophages that release PDGF and TGF-ß to further attract fibroblasts and smooth muscle cells to the wound. Macrophages are also responsible for removing nonfunctional host cells, bacteria, damaged matrix, and foreign debris from the wound site.7
Fibroblasts, recruited by PDGF, produce the new matrix needed to restore structure and function to the injured tissue. Fibroblasts attach to the cables of the provisional fibrin matrix and begin to produce collagen7
This phase is characterized by continued synthesis and degradation of the extracellular matrix components to establish a new skin matrix.7
Collagenase enzymes act on collagen to break it into smaller fragments. The extracellular matrix is then rebuilt to provide strength to mature scar tissue.7
Because REGRANEX gel is indicated for diabetic neuropathic ulcers that extend into the subcutaneous tissue or beyond, it is not indicated for use during this phase of healing.5
The impact of diabetic foot disease
Diabetic foot disease affects millions around the world and the prevalence is increasing in the US.18,19,21Review prevalence data
Do you treat wounds like these?
See how treatment with REGRANEX gel along with good ulcer care helped two diabetic foot ulcers completely heal.Review case studies
Breaking the cycle of inflammation10
Debridement helps remove the necrotic burden in diabetic foot ulcers and other types of chronic wounds.*
*Reference: Enoch S, Harding K. Wound bed preparation: the science behind the removal of barriers to healing. Wounds. 2003;15:213-229.