The REGRANEX gel dosing calculator makes dosing simple

Wound size:

REGRANEX gel dose

How to calculate a dose of REGRANEX gel

Dosing calculation5

(Ulcer length cm) x (Ulcer width cm) ÷ 4 = Length of gel to be applied (cm)

Sample calculation for an ulcer:
(3cm) x (2cm) ÷ 4 = 1.5cm → Apply 1.5cm of REGRANEX gel

  • Calculating the amount of REGRANEX gel to use will depend on the size of the ulcer area
    — In the event of multiple wounds, each ulcer should be assessed individually
  • Dose should be recalculated at weekly or biweekly intervals, based on the rate of change in the ulcer area
  • Applying more than the calculated amount of REGRANEX gel has not been shown to be beneficial
  • Please note that the estimates are only intended as a guide, contain rounded values where appropriate, and assume a constant wound size throughout the treatment period. Therefore, you should adjust these estimates based upon your own clinical experience and individual wound characteristics. Not intended to supersede independent clinical judgment or institutional protocols

Estimated tubes of REGRANEX gel based on ulcer area and length of treatment5

Not intended to supersede independent clinical judgment or institutional protocols. While each 15g tube of REGRANEX gel is estimated to dispense 60cm of gel, the actual centimeters from each tube may vary based on user characteristics and application methods.

Ulcer area 7 days
of therapy*
14 days
of therapy*
30 days
of therapy*
1-2cm2 1 tube 1 tube 1 tube
3-5cm2 1 tube 1 tube 1 tube
6-8cm2 1 tube 1 tube 1 tube
9-10cm2 1 tube 1 tube 2 tubes
11-13cm2 1 tube 1 tube 2 tubes
14-16cm2 1 tube 1 tube 2 tubes
17cm2 1 tube 1 tube 3 tubes
18cm2 1 tube 2 tubes 3 tubes
19-21cm2 1 tube 2 tubes 3 tubes
22-24cm2 1 tube 2 tubes 3 tubes

Number of tubes calculation5

(Length of gel per application cm) x (Estimated length of therapy days) ÷ (60cm/tube) = Estimated number of tubes

Sample calculation for a 3cm x 2cm ulcer:

(1.5cm) x (14 days) ÷ 60cm/tube = 0.35 tubes → Order one tube of REGRANEX gel

In a clinical study, patients who healed with REGRANEX gel received an average of 1.5 tubes16

*Days of therapy per tube calculated based on a constant ulcer size. Days of therapy per tube may change based on decreasing wound size as ulcer heals.17 If the ulcer does not decrease in size by approximately 30% after 10 weeks of treatment or complete healing has not occurred in 20 weeks, continued treatment with REGRANEX gel should be reassessed.5

Administering REGRANEX gel

Patients or caregivers can follow this once-daily, three-step flexible application process.

Review administration
Lay the foundation for healing

Good ulcer care practices alone are often not enough to stop ulcers from becoming chronic.12 Consider administering REGRANEX gel as an adjunct.

Review ulcer care
Important Safety Information

REGRANEX gel is indicated for the treatment of lower extremity diabetic neuropathic ulcers that extend into the subcutaneous tissue or beyond and have an adequate blood supply when used as an adjunct to, and not a substitute for, good ulcer care practices.

Malignancies distant from the site of application have been reported in both a clinical study and in posmarketing use. The benefits and risks of REGRANEX gel treatment should be carefully evaluated before prescribing in patients with known malignancy.

See complete prescribing information for more details.

Show References

  1. Moulik PK, Mtonga R, Gill GV. Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology. Diabetes Care. 2003;26:491-494.
  2. Armstrong DG, Wrobel J, Robbins JM. Guest editorial: are diabetes-related wounds and amputations worse than cancer? Int Wound J. 2007;4:286-287.
  3. American Cancer Society. Cancer Facts & Figures 2014. Available at: https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2014/cancer-facts-and-figures-2014.pdf. Accessed May 5, 2017.
  4. Wieman TJ, Smiell JM, Su Y. Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomized placebo-controlled double-blind study. Diabetes Care. 1998;21:822-827.
  5. REGRANEX gel Prescribing Information.
  6. Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 1999;79:1283-1316.
  7. Diegelmann RF, Evans MC. Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci. 2004;9:283-289.
  8. Guo S, DiPietro LA. Factors affecting wound healing. J Dent Res. 2010;89:219-229.
  9. Snyder RJ, Hanft JR. Diabetic foot ulcers—effects on quality of life, costs, and mortality and the role of standard wound care and advanced-care therapies in healing: a review. Ostomy Wound Manage. 2009;55:28-38.
  10. Edmonds M, Foster AV, Vowden P. Wound bed preparation for diabetic ulcers. In: Moffatt C, ed. European Wound Management Association (EWMA). Position Document: Wound Bed Preparation in Practice. London, England: MEP Ltd; 2004:6-11.
  11. Steed DL, Attinger C, Colaizzi T, et al. Guidelines for the treatment of diabetic ulcers. Wound Repair Regen. 2006;14:680-692.
  12. Snyder RJ, Kirsner RS, Warriner RA III, Lavery LA, Hanft JR, Sheehan P. Consensus recommendations on advancing the standard of care for treating neuropathic foot ulcers in patients with diabetes. Ostomy Wound Manage. 2010;56(4 Suppl):S1-S24.
  13. Papanas N, Maltezos E. Benefit-risk assessment of becaplermin in the treatment of diabetic foot ulcers. Drug Saf. 2010;33:455-461.
  14. Falanga V. Wound bed preparation: science applied to practice. In: Moffatt C, ed. European Wound Management Association (EWMA). Position Document: Wound Bed Preparation in Practice. London, England: MEP Ltd; 2004:2-5.
  15. Delamater AM. Improving patient adherence. Clin Diabetes. 2006;24:71-77.
  16. Lantis JC II, Boone D, Gendics C, Todd G. Analysis of patient cost for recombinant human platelet-derived growth factor therapy as the first-line treatment of the insured patient with a diabetic foot ulcer. Adv Skin Wound Care. 2009;22:167-171.
  17. Data on file. Smith & Nephew. October 2012.
  18. Frykberg RG, Zgonis T, Armstrong DG, et al; American College of Foot and Ankle Surgeons. Diabetic foot disorders: a clinical practice guideline (2006 revision). J Foot Ankle Surg. 2006;45(5 Suppl):S1-S66.
  19. Huang ES, Basu A, O’Grady M, Capretta JC. Projecting the future diabetes population size and related costs for the US. Diabetes Care. 2009;32:2225-2229.
  20. Boulton AJ. The diabetic foot: grand overview, epidemiology and pathogenesis. Diabetes Metab Res Rev. 2008;24 Suppl 1:S3-S6.
  21. International Working Group on the Diabetic Foot. Time to act. Available at: https://www.worlddiabetesfoundation.org/sites/default/files/Diabetes%20and%20Foot%20care_Time%20to%20act.pdf. Accessed May 9, 2017.
  22. Adeshara KA, Diwan AG, Tupe RS. Diabetes and complications: cellular signalling pathways, current understanding and targeted therapies. Curr Drug Targets. 2016;17:1309-1328.
  23. Kirsner RS. The standard of care for evaluation and treatment of diabetic foot ulcers. The University of Michigan Medical School. The University of Michigan Health System’s Educational Services for Nursing. Barry University School of Podiatric Medicine 2010. Available at: http://www.barry.edu/includes/docs/continuing-medical-education/diabetic.pdf. Accessed May 5, 2017.

Important Safety Information: REGRANEX gel is indicated for the treatment of lower extremity diabetic neuropathic ulcers that extend into the subcutaneous tissue or beyond and have an adequate blood supply when used as an adjunct to, and not a substitute for, good ulcer care practices.

Important Safety Information: REGRANEX gel is indicated for the treatment of lower extremity diabetic neuropathic ulcers that extend into the subcutaneous tissue or beyond and have an adequate blood supply when used as an adjunct to, and not a substitute for, good ulcer care practices.